Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy.
Kim E KortekaasSaskia J A M SantegoetsLiselotte TasIlina EhsanPornpimol CharoentongHelena C van DoornMariette I E van PoelgeestDana A M MustafaSjoerd H Van der BurgPublished in: Journal for immunotherapy of cancer (2022)
An active immune signaling profile is present in 35% of primary FIGO I-III VSCCs, suggesting potential responsiveness to neoadjuvant PD-1/PD-L1 immunotherapy.