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The compatibility of oxytocin and tranexamic acid injection products when mixed for co-administration by infusion for the treatment of postpartum haemorrhage: An in vitro investigation.

Pete LambertAlessandra TomazziniPhilip WrightClaire McEvoyIoannis D GallosAnne AmmerdorfferLester ChineryArri CoomarasamyAhmet Metin Gülmezoglu
Published in: BJOG : an international journal of obstetrics and gynaecology (2023)
In a clinical setting, mixing certain oxytocin and tranexamic acid products before administration may result in an underdosing of oxytocin, compromising care in an emergency life-threatening situation. The mixing of oxytocin and tranexamic acid injection products for co-administration with intravenous infusion fluids should be avoided until the exact nature of the observed interaction and its implications are understood.
Keyphrases
  • healthcare
  • emergency department
  • public health
  • palliative care
  • ultrasound guided
  • quality improvement
  • pain management