High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism.
Anni FanOladayo OladiranXiang Qun ShiJi ZhangPublished in: Journal of neuroinflammation (2020)
Overall, this study provides evidence that an HSD has a long-term impact on physiological function. CCR2-mediated cellular response, including myeloid cell trafficking and associated inflammation, plays pivotal roles in salt-dietary modulation of pain sensitivity.