Effect of delayed onset prostacyclin on markers of endothelial function and damage after subarachnoid hemorrhage.

Mikkel Gybel-BraskRune RasmussenJakob StensballePär I JohanssonSisse R Ostrowski

Published in: Acta neurochirurgica (2017)

We did not find any effects on markers of sympathoadrenal activation, endothelial damage and activation, or glycocalyx degradation of delayed onset prostacyclin infusion compared to placebo. Further trials investigating early onset endothelial repair using prostacyclin are warranted.

Keyphrases

early onset
subarachnoid hemorrhage
pulmonary arterial hypertension
brain injury
late onset
endothelial cells
cerebral ischemia
oxidative stress
pulmonary hypertension
low dose
double blind
phase iii