Osmium(VI) nitride triggers mitochondria-induced oncosis and apoptosis.

Meng YeWan-Qiong HuangZi-Xin LiChuan-Xian WangTao LiuYunZhou ChenCatherine Hong-Huan HorWai-Lun Man Wen-Xiu Ni

Published in: Chemical communications (Cambridge, England) (2022)

We report a new osmium(VI) nitrido complex bearing a nonplanar tetradentate ligand with potent anticancer activity. This complex causes mitochondrial damage, which induces liver cancer cell death via oncosis and apoptosis. This is the first osmium-based anticancer candidate that induces oncosis.

Keyphrases

cell death
cell cycle arrest
oxidative stress
diabetic rats
endoplasmic reticulum stress
high glucose
pi k akt
cell proliferation
drug induced
reactive oxygen species
gold nanoparticles
visible light
stress induced