Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma.

Wenqin LuoGuan Ning LinWeichen SongYu ZhangHuadong LaiMan ZhangJuju MiaoXiaomu ChengYongjie WangWang LiWenxiang WeiWei-Qiang GaoRu YangJia Wang

Published in: BMC biology (2021)

In sum, our study revealed the cellular and spatial organization of the detailed states of cerebellar granule cells and provided direct evidence for the similarities and discrepancies between normal cerebellar development and tumorigenesis.

Keyphrases

induced apoptosis
single cell
cell cycle arrest
preterm infants
signaling pathway
high throughput
oxidative stress
cell proliferation