Involvement of miR-145 in the development of aortic dissection via inducing proliferation, migration, and apoptosis of vascular smooth muscle cells.

Wenhui HuangCheng HuangHuanyu Ding JianFang LuoYuan LiuRuixin FanFei XiaoXiaoping FanZhisheng Jiang

Published in: Journal of clinical laboratory analysis (2019)

miR-145 was found to be downregulated in patients with AD, which induced the proliferation, migration, and apoptosis of VSMCs by targeting SMAD3. This suggested the involvement of miR-145 in the pathogenesis of AD.

Keyphrases

vascular smooth muscle cells
cell proliferation
long non coding rna
long noncoding rna
aortic dissection
oxidative stress
endoplasmic reticulum stress
signaling pathway
angiotensin ii
cell death
epithelial mesenchymal transition
diabetic rats
transforming growth factor
drug induced