RNA expression profiling of peritoneal metastasis from pancreatic cancer treated with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC).
Sönke DetlefsenMark BurtonAlan P AinsworthClaus FristrupMartin GraversenPer PfeifferLine S TarpgaardMichael Bau MortensenPublished in: Pleura and peritoneum (2024)
In regressive fibrosis of PM-PC after systemic chemotherapy and PIPAC (Regression), downregulation of mRNAs related to key tumor biological pathways was identified. Regression also showed transcriptional differences from unspecific, benign fibrosis (Controls). Future studies should explore whether mRNA profiling of PBs with PM from PC or other primaries holds prognostic or predictive value.
Keyphrases
- particulate matter
- air pollution
- water soluble
- locally advanced
- polycyclic aromatic hydrocarbons
- heavy metals
- gene expression
- cell proliferation
- genome wide
- current status
- transcription factor
- signaling pathway
- squamous cell carcinoma
- liver fibrosis
- rectal cancer
- case control
- binding protein
- risk assessment
- newly diagnosed