Transition metal-free approach for late-stage benzylic C(sp 3 )-H etherifications and esterifications.
Yu ZhangPrakash Kumar SahooPeng RenYuman QinRobin CauwenberghPhilippe NimmegeersGandhi SivaRamanSteven Van PasselAndrea GuidettiShoubhik DasPublished in: Chemical communications (Cambridge, England) (2022)
We report a transition metal-free approach for the regioselective functionalization of benzylic C(sp 3 )-H bonds using alcohols and carboxylic acids as the nucleophiles. This straightforward and general route has provided various benzylic ethers and esters, including twelve pharmaceutically relevant compounds.
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