Discontinuation of non-anti-TNF drugs for rheumatoid arthritis in interventional versus observational studies: a systematic review and meta-analysis.

Fernanda S ToninLaiza M SteimbachLeticia P LeonartVinicius L FerreiraHelena H BorbaThais PiazzaAriane G AraújoFernando Fernandez-LllimosRoberto PontaroloAstrid Wiens

Published in: European journal of clinical pharmacology (2018)

The discontinuation rates reported for non-anti-TNF drugs varied relative to the study design in which they were investigated. Regulatory agencies, price-setting entities, and evidence-gathering researchers should consider the effect of the real-life environment in their decisions and conclusions.

Keyphrases

rheumatoid arthritis
disease activity
interstitial lung disease
ankylosing spondylitis
atomic force microscopy
mass spectrometry
drug induced
systemic lupus erythematosus
idiopathic pulmonary fibrosis
high resolution
systemic sclerosis
high speed