HDAC2 dysregulation in the nucleus basalis of Meynert during the progression of Alzheimer's disease.

Laura J MahadyM NadeemM Malek-AhmadiK ChenS E PerezElliott J Mufson

Published in: Neuropathology and applied neurobiology (2018)

These findings suggest that HDAC2 dysregulation contributes to cholinergic nbM neuronal dysfunction, NFT pathology, and cognitive decline during clinical progression of AD.

Keyphrases

cognitive decline
mild cognitive impairment
histone deacetylase
oxidative stress
subarachnoid hemorrhage