A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients.

Andrew Y F Li YimJessica R de BruynNicolette W DuijvisCatriona SharpEnrico FerreroWouter J de JongeManon E WildenbergMarcel M A M MannensChristianne J BuskensGeert R D'HaensPeter HennemanAnje A Te Velde

Published in: PloS one (2018)

Our research provides evidence that the methylome and the transcriptome are systematically dysregulated in stenosis-associated fibroblasts.

Keyphrases

end stage renal disease
gene expression
ejection fraction
newly diagnosed
chronic kidney disease
dna methylation
extracellular matrix
prognostic factors
rna seq
single cell