Opportunities and challenges in using instrumental variables to study causal effects in nonrandomized stress and trauma research.

IV approaches have strengths and weaknesses compared with confounder-control approaches. IVs offers a promising complementary study design to improve evidence about the causal effects of exposures on outcomes relevant to stress and trauma. Collaboration with scientists who are experienced with identifying and analyzing IVs will support this work. (PsycInfo Database Record (c) 2022 APA, all rights reserved).