Comparative efficacy and safety of hypnotics for insomnia in older adults: a systematic review and network meta-analysis.

Hsiao-Yean Chiu Hsin-Chien LeeJen-Wei LiuShi-Jun HuaPin-Yuan ChenPei-Shan TsaiYu-Kang Tu

Published in: Sleep (2021)

Considering study quality and the potential adverse effects of benzodiazepines and nonbenzodiazepines, low-dose doxepin seems to be the optimal pharmacotherapy for the improvements in total sleep time and sleep efficiency. Future RCTs investigating the treatment effects of hypnotics, particularly low-dose doxepin, on insomnia in older adults are warranted. PROSPERO Registration number: CRD42016046301.

Keyphrases

low dose
sleep quality
physical activity
high dose
depressive symptoms
emergency department
current status
smoking cessation
quality improvement
risk assessment
combination therapy
electronic health record