No replicating evidence for anti-amyloid-β autoantibodies in cerebral amyloid angiopathy-related inflammation.

Emma van den BergRian RoelofsLieke JäkelSteven M GreenbergAndreas CharidimouEllis S Van EttenDelphine BocheCatharina J M Klijn Floris H B M Schreuder Hinke B Kuiperij Marcel M Verbeek

Published in: Annals of clinical and translational neurology (2024)

We were unable to reproduce the reported elevation of anti-Aβ autoantibody concentration in CSF of CAA-RI patients. Our findings instead support nonspecific detection of IgG levels in CSF by the assay. Reviewed CAA-RI case reports suggested a widespread cerebral inflammatory reaction. In conclusion, our findings do not support anti-Aβ autoantibodies as a diagnostic biomarker for CAA-RI.

Keyphrases

end stage renal disease
oxidative stress
systemic lupus erythematosus
subarachnoid hemorrhage
chronic kidney disease
newly diagnosed
prognostic factors
high throughput
case report
blood brain barrier
loop mediated isothermal amplification
real time pcr
drug induced