Morphologic, immunophenotypic, molecular genetic, and clinical characterization in patients with SRSF2-mutated acute myeloid leukemia.

Joshua TatarianNatalie Tupper BsPeng LiJulie FeusierMaryam AbdoStephen HyterPatrick R GonzalesDa ZhangJanet WoodroofSarah KeltingAndrew K Godwin Wei Cui

Published in: American journal of clinical pathology (2023)

Acute myeloid leukemia with altered SRSF2 shows a variable degree of morphologic dysplasia without uniform immunophenotypic aberrancies. SRSF2 mutations appear to be independent poor prognostic factors, but allo-SCT has improved the clinical outcomes in patients with SRSF2-mutant AML.

Keyphrases

acute myeloid leukemia
prognostic factors
allogeneic hematopoietic stem cell transplantation
gene expression
copy number