Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality.

Lu ZhangQingya LiJing YangPenghui XuZhe XuanJianghao XuZekuan Xu

Published in: Cancer communications (London, England) (2022)

This study revealed a critical role and regulatory mechanism of TGM2 on STAT1 in GC and highlighted the potential of TGM2 as a therapeutic target, which elucidates the development of medicine or strategies by regulating the GTP-binding activity of TGM2 in GC.

Keyphrases

cell proliferation
dna binding
transcription factor
gas chromatography
binding protein
climate change
simultaneous determination