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Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study.

Ting-Chi YehDer-Cherng LiangJen-Yin HouTang-Her JaingDong-Tsamn LinChao-Ping YangChing-Tien PengIou-Jih HungKai-Hsin LinChih-Cheng HsiaoShiann-Tarng JouShyh-Shin ChiouJiann-Shiuh ChenShih-Chung WangTe-Kau ChangKang-Hsi WuJiunn-Ming SheenHsiu-Ju YenShih-Hsiang ChenMeng-Yao LuMeng-Ju LiTai-Tsung ChangTing-Huan HuangYu-Hsiang ChangShu-Huey ChenYung-Li YangHsiu-Hao ChangBow-Wen ChenPei-Chin LinChao-Neng ChengYu-Hua ChaoShang-Hsien YangYu-Mei Y ChaoHsi-Che Liu
Published in: Cancer (2018)
The delay of the first TIT until the clearance of circulating blasts and the total omission of CrRT did not compromise survival or CNS control in patients with childhood ALL, including those with a non-CNS-1 status.
Keyphrases
  • acute lymphoblastic leukemia
  • blood brain barrier
  • childhood cancer
  • allogeneic hematopoietic stem cell transplantation
  • stem cells
  • radiation therapy
  • combination therapy
  • bone marrow
  • cell therapy