A Pretargeted Imaging Strategy for EGFR-Positive Colorectal Carcinoma via Modulation of Tz-Radioligand Pharmacokinetics.

Lin QiuQingyu LinZhan SiHui TanGuobing LiuJun ZhouTingting WangYue ChenYingzhao HuangTao YuMingzhi JinDengfeng ChengHongcheng Shi

Published in: Molecular imaging and biology (2020)

Our novel pretargeted imaging strategy (cetuximab-TCO/[99mTc]HYNIC-polypeptide-PEG11-Tz) was useful for imaging CRC, broadening the application scope of pretargeted imaging strategy. The pretargeted imaging strategy clearly delineated HCT116 tumor, showing that its use could be extended to selection of internalizing antibodies.

Keyphrases

high resolution
tyrosine kinase
fluorescence imaging
cell death
cell proliferation
photodynamic therapy