Common single-nucleotide polymorphisms combined with a genetic risk score provide new insights regarding the etiology of gestational diabetes mellitus.

Xiangnan FangLi JinMengyang TangWenqian LuSiyu LaiRong ZhangHong ZhangFeng JiangMingjuan LuoCheng Hu

Published in: Diabetic medicine : a journal of the British Diabetic Association (2022)

These findings indicate that GDM may share a common genetic background with T2D and obesity and that SNPs associated with insulin secretion defects have a vital role in the development of GDM.

Keyphrases

genome wide
metabolic syndrome
insulin resistance
copy number
type diabetes
pregnant women
weight loss
dna methylation
weight gain
high fat diet induced
adipose tissue
gene expression