Association between Serum Uric Acid Levels, Nutritional and Antioxidant Status in Patients on Hemodialysis.

Patients with hyperuricemia had higher creatinine (11.9 vs. 10.5 mg/dL; p = 0.004), potassium (5.5 vs. 5.0 mg/dL; p = 0.014) levels; phase angle (5.8 vs. 4.9; p = 0.005), protein consumption (normalized protein nitrogen appearance, nPNA, 1.03 vs. 0.83; p = 0.013) than normouricemic patients. DPPH● scavenging activity was higher in hyperuricemic subjects (1.139 vs. 1.049 mM Trolox equivalents; p = 0.007); likewise, hyperuricemic subjects had less oxidant damage measured by MDA (10.6 vs. 12.7 nmol/mL; p = 0.020). Subjects with normouricemia were at higher risk of having a reactance to height (Xc/H) ratio less than 35 (OR 2.79; 95% CI, 1.1-7.017, p = 0.028); nPNA < 1.0 (OR 3.78; 95% CI, 1.4-10.2, p = 0.007), diagnosis of cachexia (OR 2.95; 95% CI, 1156-7.518, p = 0.021), potassium levels <5 (OR 2.97; 95% CI, 1.136-7.772, p = 0.023) and PA < 5.5° (OR 3.38; 95% CI, 1.309-8.749, p = 0.012.) Conclusions: Patients with hyperuricemia had higher antioxidant capacity and better nutritional status. Purines and protein restrictions in HD patients with hyperuricemia need to be reviewed individually for each patient. More studies are needed to stablish a cut point of UA levels in renal population.