The therapeutic effect of mesenchymal stem cells on pulmonary myeloid cells following neonatal hyperoxic lung injury in mice.
Ali Al-RubaieAndrea F WiseFoula SozoRobert De MatteoChrishan S SamuelRichard HardingSharon D RicardoPublished in: Respiratory research (2018)
Our findings suggest that hMSCs reduce neonatal lung injury caused by hyperoxia by modulation of macrophage phenotype. Not only did our cell-based therapy using hMSC induce structural repair, it limited the progression of pulmonary fibrosis.
Keyphrases
- pulmonary fibrosis
- mesenchymal stem cells
- induced apoptosis
- cell therapy
- bone marrow
- cell cycle arrest
- single cell
- pulmonary hypertension
- umbilical cord
- acute myeloid leukemia
- adipose tissue
- dendritic cells
- stem cells
- cell death
- signaling pathway
- cell proliferation
- metabolic syndrome
- oxidative stress
- pi k akt
- wild type
- smoking cessation
- replacement therapy