Impaired immune responses in the airways are associated with poor outcome in critically ill COVID-19 patients.

Clea R BarnettKelsey KrolikowskiRadu PostelnicuVikramjit MukherjeeImran SulaimanMatthew ChungLuis AngelJun-Chieh J TsayBenjamin G WuStephen T YeungRalf DuerrLudovic DesvignesKamal KhannaYonghua LiRosemary SchlugerSamaan RafeqDestiny CollazoYaa KyerematengNancy AmorosoDeepak PradhanSanchita DasLaura EvansTimothy M UyekiElodie GhedinGregg J SilvermanLeopoldo N Segal Shari B Brosnahan

Published in: ERJ open research (2024)

Our data highlight the critical role of local adaptive immunity in the airways as a key defence mechanism against primary SARS-CoV-2 infection.

Keyphrases

cystic fibrosis
immune response
sars cov
electronic health record
respiratory syndrome coronavirus
big data
dendritic cells
toll like receptor
machine learning
artificial intelligence