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Alzheimer's Disease: Cellular and Pharmacological Aspects.

Gonzalo Emiliano Aranda-AbreuFausto Rojas-DuránMaría Elena Hernández-AguilarDeissy Herrera-CovarrubiasLizbeth Donají Chí-CastañedaMaría Rebeca Toledo-CárdenasJorge Manuel Suárez-Medellín
Published in: Geriatrics (Basel, Switzerland) (2024)
Alzheimer's disease was described more than 100 years ago and despite the fact that several molecules are being tested for its treatment, which are in phase III trials, the disease continues to progress. The main problem is that these molecules function properly in healthy neurons, while neuronal pathology includes plasma membrane disruption, malfunction of various organelles, and hyperphosphorylation of Tau and amyloid plaques. The main objective of this article is the discussion of a neuronal restoration therapy, where molecules designed for the treatment of Alzheimer's disease would probably be more effective, and the quality of life of people would be better.
Keyphrases
  • cognitive decline
  • spinal cord
  • open label
  • stem cells
  • combination therapy
  • bone marrow
  • brain injury
  • spinal cord injury
  • mild cognitive impairment
  • blood brain barrier
  • smoking cessation
  • subarachnoid hemorrhage