LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Alpha-Synuclein Aggregates.

Lana M Chahine David-Erick LafontantSeung Ho ChoiHirotaka Iwaki Cornelis Blauwendraat Andrew B Singleton Michael C Brumm Roy N Alcalay Kalpana M Merchant Kelly Nicole Holohan Nudelman Alain Dagher Andrew VoQin TaoCharles S Venuto Karl D Kieburtz Kathleen L Poston Susan B Bressman Paulina Gonzalez-LatapiBrian AvantsChristopher S CoffeyDanna JenningsEduardo Tolosa Andrew D Siderowf Kenneth Marek Tatyana Simuni

Published in: medRxiv : the preprint server for health sciences (2024)

evidence of CSF alpha-synuclein aggregates. LRRK2 parkinsonism cases without evidence of alpha-synuclein aggregates as a group exhibit less severe motor manifestations and decline may have more significant cognitive dysfunction. The underlying biology in LRRK2-parkinsonism cases without evidence of alpha-synuclein aggregates requires further investigation.

Keyphrases

parkinson disease
drug induced
early onset