Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors.
Stefano ComazzettoDaniel L CassidyAndrew W DeVilbissElise C JefferyBethany R OttesenAmanda R ReyesSarah MuhThomas P MathewsBrandon ChenZhiyu ZhaoSean J MorrisonPublished in: bioRxiv : the preprint server for biology (2024)
Deletion of the ascorbate transporter, Slc23a2, increases quiescence and self-renewal potential in HSCs and multipotent progenitorsAscorbate depletion is sufficient to confer long-term self-renewal potential upon multipotent hematopoietic progenitors.