Diagnostic Role of Metagenomic Next-Generation Sequencing in Tubercular Orthopedic Implant-Associated Infection.
Boyong WangQiaojie WangMingzhang LiJinlong YuFeng JiangYujie HuGeyong GuoXiaohua ChenJin TangPei HanHao ShenPublished in: Infection and drug resistance (2024)
TB-IAI is a rare infection, which occurs after orthopedic surgery and hard to diagnose microbiologically. mNGS is a new detection technique not yet discussed in current literature as a means for TB-IAI diagnostics. Here we describe a cohort of patients with TB-IAI diagnosed by mNGS show high efficiency of mNGS for detection of this pathology and present a clinical algorithm supplementing conventional methods for TB-IAI assessment.
Keyphrases
- mycobacterium tuberculosis
- high efficiency
- loop mediated isothermal amplification
- systematic review
- machine learning
- label free
- coronary artery bypass
- dna methylation
- gene expression
- acute coronary syndrome
- neural network
- antibiotic resistance genes
- genome wide
- circulating tumor
- percutaneous coronary intervention