The Emergence of Novel Spoligotypes of Highly Drug-Resistant Mycobacterium tuberculosis Isolates in Fujian, China.
Shufang LinShuzhen WeiYong ZhaoZhisong DaiJian LinYu PangPublished in: Infection and drug resistance (2022)
Our data demonstrated that the Beijing genotype is the predominant MTB sublineage in Fujian and that the prevalence rate of infection with this MTB genotype decreases with advancing patient age. Notably, the prevalence rate of this genotype in Fujian TB patients is relatively lower than in other regions of China. In addition, the emergence of novel spoligotypes of highly drug-resistant MTB isolates highlights the urgent need for ongoing molecular genotyping surveillance in Fujian.
Keyphrases
- drug resistant
- mycobacterium tuberculosis
- multidrug resistant
- pulmonary tuberculosis
- acinetobacter baumannii
- end stage renal disease
- risk factors
- genetic diversity
- ejection fraction
- newly diagnosed
- public health
- prognostic factors
- air pollution
- case report
- peritoneal dialysis
- genome wide
- single molecule
- particulate matter
- dna methylation
- deep learning
- single cell