A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis.

Mona BensalahLaura MuraineAlexis Boulinguiez Lorenzo GiordaniVictorine AlbertVictor YthierJamila DhiabAlison OliverValentine HaniqueTeresa GidaroSophie Périé Jean Lacau St-Guily Aurélien CorneauGillian Butler-BrowneAnne Bigot Vincent Mouly Elisa Negroni Capucine Trollet

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Our data demonstrate the key role of FAPs and their cross-talk with muscle cells through a paracrine signalling pathway in fibrosis of human skeletal muscle and identify endothelin as a new druggable target to counteract human muscle fibrosis.

Keyphrases

skeletal muscle
endothelial cells
induced pluripotent stem cells
insulin resistance
type diabetes
induced apoptosis
machine learning
big data
cell death
cell proliferation
transcription factor
electronic health record
artificial intelligence