Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.

Vincenzo GrazianoAndreas DannhornHeather HulmeKate WilliamsonHannah BuckleySaadia A KarimMatthew WilsonSheng Y LeeBrajesh P KaisthaSabita IslamJames E D ThaventhiranFrances M RichardsRichard GoodwinRebecca BraisJennifer P MortonSimon J DovediAlwin G SchullerJim EylesDuncan I Jodrell

Published in: Journal for immunotherapy of cancer (2023)

The formation of eAdo promotes the development of the immunosuppressive TME in PDAC, contributing to its resistance to conventional and novel therapies. Therefore, inhibition of the adenosine pathway may represent a strategy to modulate the PDAC immune milieu and improve therapy response in patients with PDAC.

Keyphrases

protein kinase
stem cells
bone marrow
dendritic cells
single cell
cell therapy