Prediction of dementia using diffusion tensor MRI measures: the OPTIMAL collaboration.
Marco EgleSaima HilalAnil Man TuladharLukas PirpamerEdith HoferMarco DueringJames WasonRobin G MorrisMartin DichgansReinhold SchmidtDaniel TozerChristopher Li Hsian ChenFrank-Erik de LeeuwHugh Stephen MarkusPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Our results support a central role for WM alterations in dementia pathogenesis in all cohorts. DTI measures such as MD median may be a useful clinical risk predictor. The contribution of other MRI markers varied according to disease severity.