Development of a model for fibroblast-led collective migration from breast cancer cell spheroids to study radiation effects on invasiveness.
Jia MeiClaudia BöhlandAnika GeigerIris BaurKristina BernerSteffen HeuerXue LiuLaura MataiteM Camila Melo-NarváezErdem ÖzkayaAnna RuppChristian SiebenwirthFelix ThomaMatthias F KlingAnna A FriedlPublished in: Radiation oncology (London, England) (2021)
In this spheroid model and with the cell lines and fibroblast strains used, irradiation does not have a major invasion-promoting effect. 3D analysis of invasiveness allows to uncouple effects on invading cell number and maximum invasion distance when assessing radiation effects.