Association Between Human Leukocyte Antigens and Graft-Versus-Host Disease Occurrence in Allogeneic Hematopoietic Stem Cell Transplantation - A 10-Year Experience on Iranian Patients.
Mohsen HamidpourElham RoshandelHaniyeh Ghaffari NazariGhazaleh SankanianHossein BonakchiMaryam SalimiSina SalariPublished in: Archives of Iranian medicine (2022)
This study suggests that certain HLA alleles might influence the incidence and severity of acute or chronic GVHD in the context of HLA-matched sibling allo-HSCT. In addition, some specific HLA alleles help predict OS in allo-HSCT recipients. These results might be helpful in estimating the incidence of aGVHD, cGVHD, and OS as well as designing personalized therapy.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- end stage renal disease
- acute myeloid leukemia
- acute lymphoblastic leukemia
- risk factors
- endothelial cells
- chronic kidney disease
- ejection fraction
- newly diagnosed
- liver failure
- peritoneal dialysis
- risk assessment
- prognostic factors
- drug induced
- stem cells
- bone marrow
- induced pluripotent stem cells
- peripheral blood
- intensive care unit
- replacement therapy