Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients.

Raffaele PezzaniLoris BertazzaElisabetta CavedonSimona CensiJacopo MansoSara Watutantrige-FernandoGianmaria PennelliFrancesca GaluppiniSusi BarolloCaterina Mian

Published in: International journal of endocrinology (2019)

The presence of an altered expression of PTTG1 and AURKA is a negative prognostic factor associated with a more aggressive course of disease, such as an advanced stage or disease persistence. It emerges as a cell cycle process mediated by the 2 factors, in addition to the RET pathway, which can be altered in MTC patients.

Keyphrases

prognostic factors
cell cycle
end stage renal disease
cell proliferation
newly diagnosed
ejection fraction
chronic kidney disease
patient reported outcomes
long non coding rna