Dolichandrone serrulata flower improves seminal biochemical parameters and proteins in T2DM rats induced by a high-fat diet and streptozotocin.

Tarinee SawatpanichChadaporn ChaimontriAlexander Tsang-Hsien WuSitthichai IamsaardSupataechasit Yannasithinon

Published in: Pharmaceutical biology (2022)

DSF extract was able to mitigate seminal dysfunction in T2DM rats via improvements of tyrosine phosphorylation, testosterone level and biochemical substances, as well as reductions of caspase proteins. DSF may be developed as an alternative medicine in treating of T2DM male subfertility and progressive complications.

Keyphrases

high fat diet
insulin resistance
adipose tissue
oxidative stress
glycemic control
multiple sclerosis
cell death
type diabetes
risk factors
replacement therapy
metabolic syndrome
diabetic rats
signaling pathway