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Synthetic ceramic macroporous blocks as a scaffold in ectopic bone formation induced by recombinant human bone morphogenetic protein 6 within autologous blood coagulum in rats.

Nikola StokovicNatalia IvanjkoMarina MilesevicIvona Matic JelicKristian BakicViktorija RumenovicHermann OppermannLarry ShimpT Kuber SampathMarko PecinaSlobodan Vukičević
Published in: International orthopaedics (2020)
We demonstrated that macroporous ceramic blocks in a form of cylinders are promising CRMs with good handling and enhanced biomechanical properties, supporting bone formation with ABGS containing rhBMP6 within autologous blood coagulum. Hence, ABGS containing ceramic blocks should be tested in preclinical models including diaphyseal segmental defects and non-unions in larger animals.
Keyphrases
  • recombinant human
  • cell therapy
  • bone marrow
  • platelet rich plasma
  • stem cells