Downregulation of RIP3 Improves the Protective Effect of ATF6 in an Acute Liver Injury Model.

Mei-Ying HuangDian-Wei WanJie DengWen-Jie GuoYue HuangHuan ChenDe-Lin XuZhi-Gang JiangYuan Xue Yi-Huai He

Published in: BioMed research international (2021)

Hepatocyte ATF6 has multiple roles in acute liver injury. It reduces hepatocyte necroptosis via negative feedback regulation of ER stress. In addition, ATF6 can upregulate the expression of RIP3, which is not helpful to the recovery process. However, downregulating RIP3 reduces hepatocyte necroptosis by promoting the alleviation of ER stress. The findings suggest that RIP3 could be a plausible target for the treatment of liver injury.

Keyphrases

liver injury
drug induced
endoplasmic reticulum stress
transcription factor
liver failure
cell proliferation
signaling pathway
intensive care unit
binding protein
hepatitis b virus