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Mucoepidermoid carcinoma of the head and neck: CRTC1/3 MAML 2 translocation and its prognosticators.

Stijn van WeertBirgit I Lissenberg-WitteElisabeth BloemenaC René Leemans
Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2021)
MEC of the head and neck has a favorable outcome with the exception of high-grade MEC. PNI and nodal involvement are not rare. CRTC1/3 MAML 2 fusion gene presence showed no survival benefit. The tendency for late onset of loco-regional and distant recurrence should not be underestimated.
Keyphrases
  • late onset
  • high grade
  • free survival
  • lymph node
  • early onset
  • low grade
  • genome wide
  • copy number
  • neoadjuvant chemotherapy
  • genome wide identification
  • gene expression
  • squamous cell carcinoma