TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels.

Harvinder S VirkMichael S BiddleDawn T SmallwoodCathryn A WestonEmily CastellsViona W BowmanJamie McCarthyYassine AmraniS Mark DuffyPeter BraddingKaty M Roach

Published in: British journal of pharmacology (2021)

TGFβ1 induces resistance of HLMFs to TRPA1 agonist- and H2 O2 -mediated cell death via down-regulation of TRPA1 channels. Our data suggest that therapeutic strategies which prevent TGFβ1-dependent down-regulation of TRPA1 may reduce myofibroblast survival in IPF and therefore improve clinical outcomes.

Keyphrases

cell death
transforming growth factor
epithelial mesenchymal transition
cell cycle arrest
big data
machine learning