TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels.
Harvinder S VirkMichael S BiddleDawn T SmallwoodCathryn A WestonEmily CastellsViona W BowmanJamie McCarthyYassine AmraniS Mark DuffyPeter BraddingKaty M RoachPublished in: British journal of pharmacology (2021)
TGFβ1 induces resistance of HLMFs to TRPA1 agonist- and H2 O2 -mediated cell death via down-regulation of TRPA1 channels. Our data suggest that therapeutic strategies which prevent TGFβ1-dependent down-regulation of TRPA1 may reduce myofibroblast survival in IPF and therefore improve clinical outcomes.