Combined Toxicity of the Most Common Indoor Aspergilli.
Daniela JakšićDubravko JelićNevenka KopjarŠegvić Klarić MajaPublished in: Pathogens (Basel, Switzerland) (2023)
The most common Aspergilli isolated from indoor air samples from occupied buildings and a grain mill were extracted and analyzed for their combined ( Flavi + Nigri , Versicolores + Nigri ) cytotoxic, genotoxic and pro-inflammatory properties on human adenocarcinoma cells (A549) and monocytic leukemia cells induced in macrophages (THP-1 macrophages). Metabolite mixtures from the Aspergilli series Nigri increase the cytotoxic and genotoxic potency of Flavi extracts in A549 cells suggesting additive and/or synergistic effects, while antagonizing the cytotoxic potency of Versicolores extracts in THP-1 macrophages and genotoxicity in A549 cells. All tested combinations significantly decreased IL-5 and IL-17, while IL-1β, TNF-α and IL-6 relative concentrations were increased. Exploring the toxicity of extracted Aspergilli deepens the understanding of intersections and interspecies differences in events of chronic exposure to their inhalable mycoparticles.
Keyphrases
- induced apoptosis
- cell cycle arrest
- oxidative stress
- squamous cell carcinoma
- endoplasmic reticulum stress
- endothelial cells
- air pollution
- signaling pathway
- cell proliferation
- acute myeloid leukemia
- radiation therapy
- drug delivery
- ionic liquid
- rheumatoid arthritis
- particulate matter
- drinking water
- risk assessment
- cancer therapy