Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing.
Richard StaatsRaquel RodriguesAndré BarrosLeonor Bacelar-NicolauMargarida AguiarDina FernandesSusana MoreiraAndré SimõesBruno Silva-SantosJoão Valença RodriguesCristina BarbaraAntónio Bugalho de AlmeidaLuis Ferreira MoitaPublished in: Sleep & breathing = Schlaf & Atmung (2017)
Obstructive sleep-disordered breathing is associated with a decrease in perforin-positive CD3+γδ-T cells. Although this finding was detected in lean patients without intermittent hypoxia, the reduction was only statistically significant in obese patients with severe OSA. Because CD3+γδ-T cells play an important role in the control of tumor cells, our findings are directly relevant for the study of the association of OSA and cancer.
Keyphrases
- end stage renal disease
- obstructive sleep apnea
- chronic kidney disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- metabolic syndrome
- adipose tissue
- type diabetes
- papillary thyroid
- positive airway pressure
- weight loss
- endothelial cells
- high intensity
- early onset
- bariatric surgery
- patient reported outcomes
- young adults
- bone mineral density
- sleep apnea