Diagnostic Accuracy of Blood-based Biomarkers for Pancreatic Cancer: A Systematic Review and Meta-analysis.

Laura E KaneGregory S MellotteEimear MylodRebecca M O'BrienFiona O'ConnellCroí E BuckleyJennifer ArlowKhanh NguyenDavid Mockler Aidan D MeadeBarbara M RyanStephen G Maher

Published in: Cancer research communications (2022)

In a systematic review and three-level multivariate meta-analysis, it is shown for the first time that blood-based multi-biomarker panels for the diagnosis of PDAC exhibit superior performance in comparison with single biomarkers. CA19-9 is demonstrated to have limited utility alone, and to perform poorly in patient control cohorts of both healthy and benign individuals. Multi-biomarker panels containing CA19-9 produce the best diagnostic performance overall.

Keyphrases

systematic review
meta analyses
case report
protein kinase
data analysis
case control