A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.

Irina V GrigorievaAndre OszwaldElena F GrigorievaHelga SchachnerBarbara NeudertTammo OstendorfJürgen FloegeMaja T LindenmeyerClemens D CohenUlf PanzerChristof AignerAlice SchmidtFrank GrosveldRajesh V ThakkerAndrew Jackson ReesRenate Kain

Published in: Journal of the American Society of Nephrology : JASN (2019)

These results provide new insights on the role GATA3 plays in MC development and response to injury. It also shows that GATA3 may be a novel and robust nuclear marker for identifying MCs in tissue sections.

Keyphrases

transcription factor
induced apoptosis
diabetic nephropathy
cell cycle arrest
high glucose
oxidative stress
signaling pathway
endothelial cells
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