AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth.

Hye Jin YunMin LiDong GuoSo Mi JeonSu Hwan ParkJe Sun LimSu Bin LeeRui LiuLinyong DuSeok-Ho KimTae Hwan ShinSeong-Il EyunYun-Yong ParkZhimin LuJong-Ho Lee

Published in: Journal of experimental & clinical cancer research : CR (2023)

Our findings reveal that metabolic stress-enhanced glucose-derived de novo serine biosynthesis is a critical metabolic feature of GBM cells, and highlight the potential to target SSP for treating human GBM.

Keyphrases

endothelial cells
protein kinase
induced apoptosis
blood glucose
cell wall
cell cycle arrest
machine learning
skeletal muscle
induced pluripotent stem cells
single cell
oxidative stress
blood pressure
signaling pathway
endoplasmic reticulum stress
dna methylation
stress induced
insulin resistance