RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets.
Margo TuerlingsMarcella van HoolwerffEvelyn HoutmanEka H E D SuchimanNico LakenbergHailiang MeiEnrike H M J van der LindenRob R G H H NelissenYolande Y F M RamosRodrigo Coutinho de AlmeidaIngrid MeulenbeltPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
IL11 and CHADL were among the most consistently differentially expressed genes OA pathophysiology-related genes in both bone and cartilage. As these genes were recently also identified as robust OA risk genes, they classify as attractive therapeutic targets acting on 2 OA-relevant tissues.