Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.
Joseph L Damstra-OddyEleanor C WarrenChristopher J PerryYann DesfougèresJohn-Mark K FitzpatrickJudith SchafLisa CostelloeWilliam HindEric J DownerAdolfo SaiardiRobin Simon Brooke WilliamsPublished in: British journal of pharmacology (2021)
Our findings suggest that both CBD and the abundant CBG differentially regulate mTORC1 signalling through a mechanism dependent on the activity of the upstream IPMK signalling pathway, with potential relevance to the treatment of mTOR-related disorders, including MS.
Keyphrases