Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice.

Yanbo LiuZhen LiTianning SunZhixiao LiAnne ManyandeHongbing Xiang Zhigang He

Published in: CNS neuroscience & therapeutics (2024)

These findings suggest that acetate metabolism is impaired in the hippocampus of HIRI-induced cognitive impairment mice and related to dysbiosis, leading to compromised histone acetylation.

Keyphrases

cognitive impairment
ischemia reperfusion injury
high glucose
diabetic rats
high fat diet induced
type diabetes
endothelial cells
gene expression
skeletal muscle