Therapeutic potential of aquatic Stevia extract in alleviating endoplasmic reticulum stress and liver damage in streptozotocin-induced diabetic rats.

Hediye Fahandezh SaadiMozhdeh ZamaniFarhad KoohpeymaAlireza RaeisiZahra AmirahmadiNarges RezaeiZahra JoolidehpoorMesbah ShamsSanaz Dastghaib

Published in: Molecular biology reports (2024)

These findings suggest that aquatic stevia extract mitigates ER stress in diabetic rats by modulating the IRE-1 arm of the UPR and apoptosis pathways, highlighting its potential therapeutic benefits for diabetes-related liver complications.

Keyphrases

diabetic rats
endoplasmic reticulum stress
oxidative stress
induced apoptosis
risk assessment
type diabetes
cardiovascular disease
risk factors
signaling pathway
glycemic control
metabolic syndrome
adipose tissue
radiation induced
anti inflammatory
high fat diet
cell cycle arrest