Characterising nitric oxide-mediated metabolic benefits of low-dose ultraviolet radiation in the mouse: a focus on brown adipose tissue.

Gursimran K DhamraitKunjal PanchalNaomi J FleuryTamara N AbelMathew K AncliffeRachael C CrewKevin CroftBernadette O FernandezMagdalena MinnionPrue H HartRobyn M LucasPeter J MarkMartin FeelischRichard B WellerVance MatthewsShelley Gorman

Published in: Diabetologia (2019)

Our results suggest that non-burning (low-dose) UVR suppresses the BAT 'whitening', steatotic and pro-diabetic effects of consuming a high-fat diet through skin release of nitric oxide, with some metabolic and immune pathways in iBAT regulated by UVR independently of nitric oxide.

Keyphrases

nitric oxide
high fat diet
low dose
adipose tissue
insulin resistance
nitric oxide synthase
hydrogen peroxide
high dose
wound healing
type diabetes
signaling pathway
soft tissue
metabolic syndrome
anti inflammatory
radiation induced