Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain.

Mohammed ShahidJuha O RinneMika ScheininJere VirtaPäivi MarjamäkiOlof SolinEveliina ArponenJukka SallinenKatja KuokkanenJuha Rouru

Published in: EJNMMI research (2020)

ORM-12741 is a selective α2C-AR antagonist which penetrates the rat and human brain to occupy α2C-ARs in a manner consistent with its receptor pharmacology. Trial registration number and date of registration: ClinicalTrial.cov NCT00829907. Registered 11 December 2008. https://clinicaltrials.gov/ .

Keyphrases

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